The impact of high-glucose or high-fat diets on the metabolomic profiling of mice

Objective Diets high in glucose or fat contribute to an increased prevalence of the diseases. Therefore, objective current research was observe and evaluate impact dietary components on different metabolomic profiles primary tissues mice. Methods For 8 weeks, diet with high-glucose or-fat given C57BL/6 J The levels metabolites mice were studied using gas chromatography-mass spectrometry (GC-MS) analyzed multivariate statistics. Results By comparing metabolic between two groups control group main tissues, our study revealed 32 (HGD) 28 high-fat (HFD) group. most significantly altered amino acids (AAs; L-alanine, L-valine, glycine, L-aspartic acid, L-isoleucine, L-leucine, L-threonine, L-glutamic phenylalanine, tyrosine, serine, proline, lysine), fatty (FAs; propanoic 9,12-octadecadienoic pentadecanoic hexanoic myristic acid), organic compounds (succinic malic citric L-(+)-lactic myo-inositol, urea). These are implicated many pathways related energy, AAs, lipids metabolism. Conclusion We systematically changes underlying diet. divergent diets induced patent AA lipid metabolism helped identify a mouse model.